How to Feel Better on GLP1s (Ozempic, Wegovy, etc.)—Real Talk from a Doctor

by Dr. Jen Caudle

💊 GLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound have become game-changers for weight loss and blood sugar control—but let’s be honest, they can do a number on your stomach.

If you’re dealing with nausea, reflux, bloating, diarrhea, constipation, or cramping—you’re not alone. These GI side effects are common and can be frustrating. The good news? There are real, practical ways to make things better. Let’s get into it. (Oh, and did you see how Ozempic can improve the appearance of things "down there?")

🥴 First, Why Does This Happen?

GLP-1 meds slow down how fast your stomach empties. That’s great for curbing hunger and controlling blood sugar—but not so great when it leads to nausea, gas, or trips to the bathroom. GLP1s do other things as well: they increase how full you feel after eating. They also block glucagon secretion (glucagon is a hormone that increases blood sugar levels when needed) and trigger your pancreas to release insulin.

🥗 Lifestyle Tips That Can Actually Help

1. Slow Down at Mealtime

Eat mindfully, chew thoroughly, and don’t rush. Eating too quickly can trigger nausea and bloating. Listen to your body—stop when you’re full.

2. Think Small (Portions, That Is)

Large, heavy meals = recipe for tummy trouble. Try smaller, balanced meals more often throughout the day.

3. Stay Upright After Eating

Don’t lie down right after meals. Give your stomach time to digest and reduce reflux risk.

4. Ditch the Straw

Straws can cause you to swallow extra air, which can lead to gas and bloating. Drink straight from the cup when you can.

5. Hydrate Smartly

Drink water regularly—but don’t chug it all at once. Overhydration can sometimes make symptoms worse. Sip throughout the day.

6. Limit Fatty, Greasy, and Sugary Foods

Fried and rich foods are harder to digest and can make nausea or bloating worse. Stick to low-fat, simple meals while your body adjusts.

7. Move Your Body

Even light exercise (like walking) can help your digestion. It can also ease constipation and bloating.

💊 Medications That May Help (just make sure to run these by your doctor)

If lifestyle changes aren’t cutting it, some over-the-counter or prescription options might make a big difference:

• Stool softeners for constipation

• Anti-nausea meds if you’re feeling queasy

• Ginger or bland foods (hello, saltines) to settle the stomach

• Anti-diarrheals for loose stools

Still struggling? Talk to your doctor—there may be other options or an investigation that is needed.

🚽 Pay Attention to Your Bowel Habits: It May Not Be the Meds!

Changes in your bathroom routine can happen—but don’t ignore them. If you go from daily poops to once a week, or suddenly develop diarrhea, talk to your doctor. Sometimes it's just the medication… but sometimes it's something more.

🚩 Red flags to watch for:

• Blood in your stool

• Black, tar-like stools

• Severe or persistent abdominal pain

• Vomiting or diarrhea that won’t quit

These symptoms are not typical side effects. Don’t wait—get checked out. (There are other potential warning signs too- bottom line is to listen to your body!)

🩺 Work With Your Doctor to Adjust Meds

If the side effects are too much, your dose may need a little tweaking:

• Start low and go slow. Many people feel better once their body adjusts—but ramping up too quickly can make side effects worse.

• Take a step back. Sometimes lowering the dose or taking a brief break helps.

• Try a different medication. Some people tolerate one GLP-1 better than another—switching might be worth exploring.

❤️ Final Thoughts from Your Friendly Doc

Yes, GLP-1 meds can be tough on your tummy—but there’s so much you can do to feel better. With a little patience, a few tweaks to your routine, and some guidance from your doctor, you don’t have to suffer through it.

Your health journey doesn’t have to be miserable. You’ve got options—and you’ve got support.

xoxo, Dr. Jen

PS - If you don't feel you're losing weight on GLP1s, please watch this video!

Dr. Jen Caudle is a board-certified Family Physician, Associate Professor at Rowan University,  tv health expert, and video creator. I invite you to subscribe to my Meditation Channel on YouTube.  Also, follow me on Facebook, YouTube, Instagram, and TikTok. Also sign up for my free health newsletter at www.drjencaudle.com.